解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The role of retrograde signaling between target cells and their presynaptic partners during early cell-cell interactions was examined in cell culture. Using time-lapse video microscopy and fura-2 calcium analysis, we followed contacts between presynaptic neurites of Helisoma motoneurons and muscle fibers dissociated f...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1176
更新日期:1993-07-01 00:00:00
abstract::In the spawned Xenopus egg, germ plasm is found as cytoplasmic islands spread over a wide cortical region of the vegetal pole. However, by the blastula stage, the same material is found concentrated into a few large blastomeres at the floor of the blastocoel. Components of the germ plasm can be specifically labeled wi...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1142
更新日期:1993-06-01 00:00:00
abstract::The smaller AB-cell of the 2-cell embryo of Tubifex divides 40 min later than the larger CD-cell. The present study was undertaken to elucidate those factors that are responsible for this cleavage asynchrony. An examination of chromosome cycles showed that the AB-cell entered M-phase 5 min later and spent about 35 min...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1123
更新日期:1993-05-01 00:00:00
abstract::Gr16 (chromosome 2, 6.9 cM) is a dominant, grey egg mutation of the domestic silkmoth, Bombyx mori, which produces an opaque instead of a translucent chorion. To determine the underlying cause of this defect, we examined the effects of the mutation on chorion ultrastructure, protein accumulation, and biosynthesis patt...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1112
更新日期:1993-05-01 00:00:00
abstract::Mutations at the murine steel (Sl) locus encoding the ligand for the c-kit receptor result in defects in gametogenesis, hematopoiesis, and melanogenesis. Steel Panda (Slpan) is an allele at the Sl locus obtained by an X-ray mutagenesis protocol. Slpan/Slpan homozygotes are mildly anemic black-eyed whites with pigmente...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1115
更新日期:1993-05-01 00:00:00
abstract::An antiserum (anti-H2) directed at the second helix of the helix-loop-helix (HLH) protein MyoD1 reacts with a protein expressed during avian cardiac myocyte differentiation. Indirect immunohistochemical whole mount staining with anti-H2 detected a protein expressed in stage 11 hearts, but not in hearts of older embryo...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1088
更新日期:1993-04-01 00:00:00
abstract::Similar amounts of expression of a luciferase reporter gene that is driven by the SV40 early promoter are detected in G2 of 1-cell mouse embryo following injection of the male pronucleus in either early or mid/late S. No luciferase activity is observed when the male pronucleus is injected in early S and the embryos an...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1101
更新日期:1993-04-01 00:00:00
abstract::Mature hamster eggs exhibit repetitive increases in the intracellular Ca2+ concentration ([Ca2+]i) at fertilization, caused by inositol 1,4,5-trisphosphate (InsP3)-induced Ca2+ release (IICR) from stores. Oscillating Ca2+ rises also occurred in inseminated immature oocytes at the germinal vesicle (GV) stage but the pe...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1059
更新日期:1993-03-01 00:00:00
abstract::The distribution of the extracellular matrix protein tenascin was studied in the developing chick visual system to determine its possible regulatory role in retinotectal development. Little tenascin was present in the retinal optic fiber layer, and the optic nerve and tract, but was abundant in the stratum opticum of ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1076
更新日期:1993-03-01 00:00:00
abstract::Expression of cardiac troponin I (TnIcardiac) and slow skeletal troponin I (TnIslow) genes was analyzed at the mRNA and protein level in the developing rat heart. TnIslow mRNA was detectable by in situ hybridization in the embryonic cardiac tube as early as the 13-somite stage (Embryonic Day 10). In contrast, TnIcardi...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1074
更新日期:1993-03-01 00:00:00
abstract::The cortex and subcortical regions of the developing follicles and eggs of silkmoths are rich in cytoskeletal elements, particularly actin. In situ analysis using [3H]-polyuridylic acid and biotinylated oligo d(T) reveals a pattern of changes in poly(A)+ RNA distribution during oogenesis. The developing pattern of dis...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1031
更新日期:1993-02-01 00:00:00
abstract::Previous studies have shown that cultured Schwann cells secrete platelet-derived growth factor (PDGF) and express PDGF receptors which transmit a mitogenic response particularly when their levels are upregulated by elevation of intracellular cAMP. In this study the expression of PDGF and PDGF alpha- and beta-receptors...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1044
更新日期:1993-02-01 00:00:00
abstract::Following their birth in olfactory placode, luteinizing hormone-releasing hormone (LHRH)-containing neurons migrate across the developing cribriform plate and form a dispersed population in the mammalian basal forebrain. The present study reveals the colocalization of unique glycoconjugate antigens (detected with mono...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1045
更新日期:1993-02-01 00:00:00
abstract::The t haplotypes are variant forms of the proximal portion of chromosome 17 in the mouse. The t haplotypes alter spermatogenesis and many also contain lethal factors. Although the lethal factors vary between t haplotypes, all t haplotypes have the same effect on sperm, that of altering sperm function in fertilization....
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1002
更新日期:1993-01-01 00:00:00
abstract::Anuran amphibian embryos (Xenopus laevis and Rana dybowskii) are sensitive to novel gravitational fields. Under simulated weightlessness, (i) the location of the first horizontal cleavage furrow was shifted toward the vegetal pole at the eight-cell stage; (ii) the position of the blastocoel was more centered, and the ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1024
更新日期:1993-01-01 00:00:00
abstract::The facial primordia in the chick embryo begin as rounded swellings that surround the primitive mouth and these grow out to form the beak. The control of proximodistal outgrowth is not well understood but may involve similar mechanisms to the limb bud. In order to test this hypothesis, combinations were made between e...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90069-s
更新日期:1992-12-01 00:00:00
abstract::The contractile proteins of skeletal muscle are often represented by families of very similar isoforms. Protein isoforms can result from the differential expression of multigene families or from multiple transcripts from a single gene via alternative splicing. In many cases the regulatory mechanisms that determine the...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/0012-1606(92)90067-q
更新日期:1992-12-01 00:00:00
abstract::Although the development of several of the voltage-dependent currents in embryonic amphibian myocytes has been described, the overall muscle electrical development, particularly the relative times of expression of different voltage-dependent currents, has not been addressed in a single study under one set of condition...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90043-g
更新日期:1992-11-01 00:00:00
abstract::Microtubule organization during the novel cell division of ameiotic microsporocytes was examined using indirect immunofluorescence microscopy. A recessive mutation of the maize gene Ameiotic causes the replacement of meiosis I with a synchronized mitotic division (Palmer, R. G. (1971). Chromosoma 35, 233-246). All ide...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90063-m
更新日期:1992-11-01 00:00:00
abstract::The fertilization potential in Phallusia mammillata consisted of an initial rapid depolarization. This initial sperm-triggered depolarization was followed by a phase of membrane depolarization which was of either long or short duration, depending on the eggs. When of long duration, the phase of membrane depolarization...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90108-s
更新日期:1992-10-01 00:00:00
abstract::Plakoglobin and beta-catenin are cytoplasmic proteins associated with the intracellular plaques of cell adhesive junctions. While plakoglobin is present in both adherens junctions and desmosomes, beta-catenin is associated with the cadherins that accumulate only in adherens junctions. Both beta-catenin and plakoglobin...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90118-z
更新日期:1992-10-01 00:00:00
abstract::Most, if not all, endocrine cells seem capable of synthesizing and storing more than one hormone. Such cellular colocalization of hormones can be due either to the presence of two or more specific granules within the cells or to colocalization of the hormones within a single granule. The present study was performed to...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90122-w
更新日期:1992-10-01 00:00:00
abstract::Cell division is arguably the most fundamental developmental process for single-celled and multicellular organisms alike. The pathway from one cell division to the next is known as the cell cycle. A conserved biochemical regulatory network controls progress along this pathway in plants, animals, and yeasts. This revie...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/0012-1606(92)90087-w
更新日期:1992-09-01 00:00:00
abstract::Leaf primordia, first visible as small bumps, are produced in a cyclical pattern at the edges of the shoot apex, a smooth region at the top of the stem. Their formation is a biomechanical process. This review first considers hypothetical construction mechanisms and then summarizes research that provides information ab...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/0012-1606(92)90089-y
更新日期:1992-09-01 00:00:00
abstract::The development of supernumerary bristle precursors induced by the mutation shaggy (sgg; also known as zeste-white 3) was examined in the developing wing blade of imaginal and pupal Drosophila. sgg clones were induced by mitotic recombination; clones were marked using enhancer-trap flies which express beta-galactosida...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90134-3
更新日期:1992-08-01 00:00:00
abstract::Acidic fibroblast growth factor (aFGF) and basic fibroblast growth factor (bFGF) are present in high levels in most areas of the embryonic rodent brain. To begin to understand the role of these growth factors in brain development, the effects of aFGF and bFGF on dissociated cell cultures prepared from embryonic and ne...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90143-5
更新日期:1992-08-01 00:00:00
abstract::The ectoderm of early Xenopus gastrula is competent to become induced to neural tissue, but dorsal ectoderm is more neural competent than ventral ectoderm. It is a tenable, but as yet untested possibility that the higher neural competence of dorsal gastrula ectoderm is dependent on the presence of the dorsal mesoderm....
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90168-g
更新日期:1992-07-01 00:00:00
abstract::Germ line transformation has been used to map the cis regulatory DNA elements responsible for the precise and evolutionarily stable developmental expression of the s18 chorion gene. Constructs containing chimeric combinations of Drosophila melanogaster and D. grimshawi DNA regions, as well as D. grimshawi sequences al...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90160-i
更新日期:1992-07-01 00:00:00
abstract::Interleukin-6 is a member of a class of hormone-like molecules termed cytokines. The actions of IL-6 are highly pleiotropic. In adults IL-6 functions as a major mediator of inflammatory responses as well as inducing the synthesis of acute phase proteins by the liver following infection or injury. Based on in vitro and...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/0012-1606(92)90173-e
更新日期:1992-06-01 00:00:00
abstract::The germinal vesicle (GV) of starfish oocytes contains a factor which is required to drive the cytoplasmic cycle of the meiotic division. Biochemical investigation of this factor has been difficult due to the small quantities of obtainable GV materials. To overcome this, we have developed a mass-isolation procedure fo...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90187-l
更新日期:1992-06-01 00:00:00
abstract::It has been suggested that the mesonephros has a role in normal limb development. This hypothesis was directly tested by removing the mesonephros adjacent to the presumptive limb region of stage 12-18 chick embryos using microsurgery or laser ablation. The experimental manipulation resulted in reduced limb outgrowth o...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90230-e
更新日期:1992-05-01 00:00:00
abstract::The relationship between cellular position and growth control has been studied in cultures of dissociated fragments of mouse limb bud cells. Using cells derived from various positions along the anterior-posterior axis of the limb bud we have developed culture conditions that optimize growth of positionally isolated ce...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90208-x
更新日期:1992-05-01 00:00:00
abstract::c-fms and c-kit are structurally related tyrosine kinase receptors for colony-stimulating factor-1 (CSF-1) and for steel factor (SF), respectively. The level of c-fms mRNA, like c-kit mRNA, increases during the maturation of oocytes and is an abundant maternal message found in the unfertilized oocyte. Following fertil...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90207-w
更新日期:1992-05-01 00:00:00
abstract::A polarity in gap junctional permeability normally exists in 32-cell stage Xenopus embryos, in that dorsal cells are relatively more coupled than ventral cells, as measured by transfer of Lucifer yellow dye. The current study extends our analysis of whether gap junctional permeability at this stage can be modulated by...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90227-8
更新日期:1992-05-01 00:00:00
abstract::We examined the effects of ciliary neurotrophic factor (CNTF) and depolarization, two environmental signals that influence noradrenergic and cholinergic function, on neuropeptide expression by cultured sympathetic neurons. Sciatic nerve extract, a rich source of CNTF, increased levels of vasoactive intestinal peptide ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90242-9
更新日期:1992-04-01 00:00:00
abstract::Early (alpha) histone genes are one of several histone gene families in the sea urchin genome. They are expressed at high levels in blastula-stage embryos and are inactivated by the early gastrula stage. By microinjecting mutant early H2B genes into sea urchin zygotes and monitoring their transcriptional activity in b...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90248-f
更新日期:1992-04-01 00:00:00
abstract::The location and distribution of neural crest-derived Schwann cells during development of the peripheral nerves of chick forelimbs were examined using chick-quail chimeras. Neural crest cells were labeled by transplantation of the dorsal part of the neural tube from a quail donor to a chick host at levels of the neura...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90014-8
更新日期:1992-03-01 00:00:00
abstract::To understand cell interactions during induction of skin appendages, we studied the roles of adhesion molecules N-CAM, tenascin, integrin, and fibronectin during feather development. Tenascin appeared in a periodic pattern on epithelia and was so far the earliest molecule detected in placodes. Three placode domains we...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90009-6
更新日期:1992-03-01 00:00:00
abstract::Sequence analysis of cDNA clones encoding fibronectin (FN) from Xenopus laevis reveals extensive amino acid identities with other vertebrate FNs, including the presence of the Arg-Gly-Asp (RGD) cell attachment site in type III-10 and of a second, cell-binding site (EILDV) in the alternative spliced V region of the pro...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90291-n
更新日期:1992-02-01 00:00:00
abstract::We have examined the presence of protein kinase C in oocytes of Chaetopterus pergamentaceus and its role in the initiation of germinal vesicle breakdown (GVBD). First, we demonstrated that the oocytes contain a phospholipid- and calcium-dependent protein kinase, protein kinase C (PKC). Since PKC is the primary intrace...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90294-q
更新日期:1992-02-01 00:00:00